Dica de Saúde 09/05/2018 14:35

Colesterol no cérebro está associado a surgimento da doença de Alzheimer, diz estudo

<h2 class="content-head__subtitle" itemprop="alternativeHeadline" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: 1.45; font-family: opensans, sans-serif; vertical-align: baseline; color: rgb(102, 102, 102); letter-spacing: -0.8px; text-align: justify;"><img src="http://unisaudems.org.br/fotos/201805091012371525875157.jpg" style="font-family: Arial, Verdana, sans-serif; font-size: 12px;" alt="" /></h2> <h2 class="content-head__subtitle" itemprop="alternativeHeadline" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: 1.45; font-family: opensans, sans-serif; vertical-align: baseline; color: rgb(102, 102, 102); letter-spacing: -0.8px; text-align: justify;">&nbsp;</h2> <h2 class="content-head__subtitle" itemprop="alternativeHeadline" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: 1.45; font-family: opensans, sans-serif; vertical-align: baseline; color: rgb(102, 102, 102); letter-spacing: -0.8px; text-align: justify;"><span style="font-size: xx-large;">Pesquisadores da Universidade de Cambridge mostram que composto contribui para aglomerado de placas t&oacute;xicas associadas &agrave; doen&ccedil;a.</span></h2> <h2 class="content-head__subtitle" itemprop="alternativeHeadline" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: 1.45; font-family: opensans, sans-serif; vertical-align: baseline; color: rgb(102, 102, 102); letter-spacing: -0.8px; text-align: justify;"> <p class="content-text__container theme-color-primary-first-letter" data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">&nbsp;</span></p> <p class="content-text__container theme-color-primary-first-letter" data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">Um estudo liderado pela Universidade de Cambridge, no Reino Unido, mostra que o colesterol tamb&eacute;m tem um papel importante no surgimento e na progress&atilde;o da doen&ccedil;a de Alzheimer. Em testes feitos em laborat&oacute;rio, cientistas mostraram que a presen&ccedil;a do composto age como um &quot;gatilho&quot; para a forma&ccedil;&atilde;o de aglomerados t&oacute;xicos relacionados &agrave; condi&ccedil;&atilde;o.</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">&nbsp;</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">Chamados de prote&iacute;na beta-amiloide, h&aacute; muito tempo esses compostos s&atilde;o indicativos da progress&atilde;o da doen&ccedil;a: eles se acumulam ao redor de neur&ocirc;nios e atrapalham a transmiss&atilde;o de um impulso nervoso para o outro. Esse fato, por sua vez, explica v&aacute;rios sintomas associados, como falhas na mem&oacute;ria. Progressivamente, essa prote&iacute;na tamb&eacute;m favorece o ac&uacute;mulo de placas que deflagram a morte de c&eacute;lulas nervosas.</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">&nbsp;</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">O achado foi publicado na &quot;Nature Chemistry&quot; , mas n&atilde;o &eacute; a primeira vez que a ci&ecirc;ncia faz a rela&ccedil;&atilde;o entre colesterol e Alzheimer: estudos anteriores j&aacute; demonstraram que os mesmos genes que processam a gordura tamb&eacute;m desencadeiam a progress&atilde;o da doen&ccedil;a.</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">&nbsp;</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;"><span style="font-family: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; letter-spacing: -0.6px;">Agora, o que os pesquisadores da Universidade de Cambridge demonstraram &eacute; que o colesterol contribui para que v&aacute;rias c&eacute;lulas da beta-amiloide fiquem juntas, favorecendo &agrave; forma&ccedil;&atilde;o das placas associadas &agrave; dem&ecirc;ncia.</span></span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">&nbsp;</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;"><span style="color: rgb(72, 72, 72); letter-spacing: -0.6px; text-align: start;">Atualmente, nos consult&oacute;rios, altos n&iacute;veis de colesterol est&atilde;o relacionados ao surgimento de doen&ccedil;as cardiovasculares e diretrizes para a conten&ccedil;&atilde;o do composto t&ecirc;m o objetivo de prevenir o aparecimento de eventos card&iacute;acos, como o infarto. N&atilde;o h&aacute; clareza nesse momento, contudo, se altera&ccedil;&otilde;es na dieta podem ter impacto no Alzheimer como afeta doen&ccedil;as card&iacute;acas.</span></span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">&nbsp;</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">&nbsp;</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">Apesar disso, contudo, o achado sobre o colesterol &eacute; particularmente importante porque a beta-amiloide est&aacute; presente em n&iacute;veis baixos no c&eacute;rebro e os cientistas n&atilde;o compreendiam o que levava &agrave; agrega&ccedil;&atilde;o que contribui para o surgimento da dem&ecirc;ncia.</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">&nbsp;</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">&nbsp;</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">&quot;Os n&iacute;veis de beta-amil&oacute;ide normalmente encontrados no c&eacute;rebro s&atilde;o cerca de mil vezes menores do que o necess&aacute;rio para observ&aacute;-lo agregando em laborat&oacute;rio - ent&atilde;o, o que acontece no c&eacute;rebro para torn&aacute;-lo agregado?&quot;, descreve Vendruscolo.</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">&nbsp;</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">&nbsp;</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">Foi ent&atilde;o que os pesquisadores viram em testes&nbsp;<em style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline;">in vitro</em>&nbsp;que a presen&ccedil;a de colesterol nas membranas celulares pode atuar como um gatilho para a agrega&ccedil;&atilde;o de beta-amil&oacute;ide. Com isso, o controle do colesterol no c&eacute;rebro poderia impedir o aglomerado que favorece o surgimento da dem&ecirc;ncia.</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">&nbsp;</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;">&nbsp;</p> <span style="font-size: xx-large;"> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><em>Fonte: (G1)</em></p> </span> <p><span style="font-size: xx-large;">&nbsp;</span></p> <p><span style="font-size: xx-large;">&nbsp;</span></p> <p><span style="font-size: xx-large;">&nbsp;</span></p> <p class="content-text__container " data-track-category="Link no Texto" data-track-links="" style="box-sizing: inherit; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: 1.25rem; line-height: inherit; font-family: inherit; vertical-align: baseline;"><span style="font-size: xx-large;">&nbsp;</span></p> <p><span style="font-size: xx-large;">&nbsp;</span></p> <p><span style="font-size: xx-large;">&nbsp;</span></p> </h2> <p style="text-align: justify;">&nbsp;</p>

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